Parimala R. Vajjhala

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

Vitaliya Sagulenko, Sara J Thygesen, David P. Sester et al. · Cell Death and Differentiation · 2013 · 485 citations · Full text

Signal Transduction, Signaling Pathway, Pyroptotic Death Pathways +9

Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein

Parimala R. Vajjhala, Ruth Mirams, Justine M. Hill · Journal of Biological Chemistry · 2012 · 184 citations · Full text

Multiple Binding Sites, Protein Function, Signal Transduction +7

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

Tian‐Min Fu, Yang Li, Alvin Lu et al. · Molecular Cell · 2016 · 175 citations · Full text

Death-inducing Signaling Complex, Signal Transduction, Protein Function +15

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Thomas Ve, Parimala R. Vajjhala, Andrew Hedger et al. · Nature Structural & Molecular Biology · 2017 · 174 citations · Full text

Signal Transduction, Natural Sciences, Molecular Biology +9

A Novel Flow Cytometric Method To Assess Inflammasome Formation

David P. Sester, Sara J Thygesen, Vitaliya Sagulenko et al. · The Journal of Immunology · 2014 · 114 citations