Concepedia

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

Sam Chen, Yuen Yi C. Tam, Paulo J.C. Lin, Molly M. H. Sung, Ying K. Tam, Pieter R. Cullis

Journal of Controlled Release · 2016 · 352 citations · 29 references

DOI

Concepts

References

29

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

Horacio Cabral, Yu Matsumoto, Kazue Mizuno et al. · Nature Nanotechnology · 2011 · 2.4K citations

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Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.8K citations

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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Jérôme Gilleron, William Querbes, Anja Zeigerer et al. · Nature Biotechnology · 2013 · 1.6K citations

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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui et al. · Angewandte Chemie International Edition · 2012 · 1.2K citations · Full text

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg et al. · Nature Biotechnology · 2008 · 1.2K citations

, , +16