Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

Nathan M. Belliveau, Jens Huft, Paulo J.C. Lin, +9

Molecular Therapy — Nucleic Acids

NanoparticlesNanotherapeuticsEngineeringLipid NanoparticlesGene Delivery +16

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

Jayesh A. Kulkarni, Maria M. Darjuan, Joanne E. Mercer, +5

ACS Nano

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Barbara L. Mui, Ying K. Tam, Muthusamy Jayaraman, +13

Molecular Therapy — Nucleic Acids

Cell-based Drug DeliveryNanomedicineEngineeringChain LengthMedicine +11

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

Alex K. K. Leung, Yuen Yi C. Tam, Sam Chen, +2

The Journal of Physical Chemistry B

NanoparticlesEthylene GlycolEngineeringLipid NanoparticlesLipid Movement +16

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

Sam Chen, Yuen Yi C. Tam, Paulo J.C. Lin, +3

Journal of Controlled Release

NanoparticlesNanomedicineEngineeringVivo PotencyLipid Nanoparticle Formulations +6

Advances in Lipid Nanoparticles for siRNA Delivery

Yuen Yi C. Tam, Sam Chen, Pieter R. Cullis

Pharmaceutics

NanoparticlesNanomedicineLipid PreparationTechnological AdvancesEngineering +12

Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA

Jayesh A. Kulkarni, J. Layne Myhre, Sam Chen, +4

Nanomedicine Nanotechnology Biology and Medicine

NanoparticlesNanomedicineDna NanotechnologyEngineeringLipid Nanoparticles +5

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration

Sam Chen, Yuen Yi C. Tam, Paulo J.C. Lin, +3

Journal of Controlled Release

NanoparticlesNanomedicineEngineeringHepatocyte GeneLipid Nanoparticle Formulations +6

Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach

T. Terada, Jayesh A. Kulkarni, Ariel Huynh, +4

Langmuir

NanoparticlesLipid AnalysisEngineeringLipid NanoparticlesGene Delivery +14

Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA

Paulo J.C. Lin, Yuen Yi C. Tam, Ismail M. Hafez, +5

Nanomedicine Nanotechnology Biology and Medicine

NanoparticlesNanomedicineLipid PreparationEngineeringCationic Lipid Composition +6