Sam Chen

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

Nathan M. Belliveau, Jens Huft, Paulo J.C. Lin et al. · Molecular Therapy — Nucleic Acids · 2012 · 646 citations · Full text

Nanoparticles, Nanotherapeutics, Engineering +18

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

Jayesh A. Kulkarni, Maria M. Darjuan, Joanne E. Mercer et al. · ACS Nano · 2018 · 581 citations

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Barbara L. Mui, Ying K. Tam, Muthusamy Jayaraman et al. · Molecular Therapy — Nucleic Acids · 2013 · 459 citations · Full text

Cell-based Drug Delivery, Nanomedicine, Engineering +13

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

Alex K. K. Leung, Yuen Yi C. Tam, Sam Chen et al. · The Journal of Physical Chemistry B · 2015 · 336 citations

Nanoparticles, Ethylene Glycol, Engineering +18

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

Sam Chen, Yuen Yi C. Tam, Paulo J.C. Lin et al. · Journal of Controlled Release · 2016 · 334 citations

Nanoparticles, Nanomedicine, Engineering +8