Sean C. Semple

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.7K citations

Lipid Preparation, Nanomedicine, Engineering +3

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc, Martin A. Maier, Muthiah Manoharan et al. · Nature Nanotechnology · 2019 · 1.5K citations · Full text

Nanomedicine, Engineering, Clinical Translation +9

Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

Arcadio Chonn, Sean C. Semple, P.R. Cullis · Journal of Biological Chemistry · 1992 · 460 citations · Full text

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures

Sean C. Semple, Sandra K. Klimuk, Troy O. Harasym et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2001 · 447 citations

Lipid Preparation, Proteinlipid Interaction, Biochemistry +7

Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo

Sean C. Semple, Arcadio Chonn, Pieter R. Cullis · Advanced Drug Delivery Reviews · 1998 · 393 citations

Proteinlipid Interaction, Signal Transduction, Biochemistry +10