Sean C. Semple

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.8K citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +16

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc, Martin A. Maier, Muthiah Manoharan et al. · Nature Nanotechnology · 2019 · 1.6K citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +16

Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

Arcadio Chonn, Sean C. Semple, P.R. Cullis · Journal of Biological Chemistry · 1992 · 461 citations · Full text

Life Sciences, Biochemistry, Pharmacokinetics +17

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures

Sean C. Semple, Sandra K. Klimuk, Troy O. Harasym et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2001 · 452 citations

Pharmacy, Biochemistry, Molecular Biology +17

Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo

Sean C. Semple, Arcadio Chonn, Pieter R. Cullis · Advanced Drug Delivery Reviews · 1998 · 396 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +14