Sandra K. Klimuk

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.8K citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +16

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures

Sean C. Semple, Sandra K. Klimuk, Troy O. Harasym et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2001 · 452 citations

Pharmacy, Biochemistry, Molecular Biology +17

Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid

Sean C. Semple, Troy O. Harasym, Kathy A. Clow et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 214 citations

Pharmacy, Immunology, Pharmacokinetics +17

Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations

Michael Johnston, Sean C. Semple, Sandra K. Klimuk et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2006 · 150 citations

Pharmacy, Pharmaceutics, Pharmacology +16

Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN

Susan de Jong, Ghania Chikh, Laura Sekirov et al. · Cancer Immunology Immunotherapy · 2007 · 132 citations · Full text

Pharmacy, Immunology, Pharmaceutics +16