Concepedia

Substituted-2-Desamino-2-Methyl-Quinazolinones. A Series of Novel Antitumour Agents

F.T. Boyle, Zbigniew S. Matusiak, L. R. HUGHES, Anthony M. Slater, T C Stephens, Marie-Louise Smith, Melody Brown, Rosemary Kimbell, Ann L. Jackman

Advances in experimental medicine and biology · 1993 · 11 citations · 3 references

DOI

Concepts

References

3

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

W.R. Montfort, Kathy M. Perry, Eric B. Fauman et al. · Biochemistry · 1990 · 230 citations

, , +15

Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate

David A. Matthews, J. Ernest Villafranca, Cheryl A. Janson et al. · Journal of Molecular Biology · 1990 · 117 citations

, , +12

The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

Ann L. Jackman, David R. Newell, William Gibson et al. · Biochemical Pharmacology · 1991 · 59 citations

, , +7