Melody Brown

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

A.L. Jackman, G A Taylor, William Gibson et al. · PubMed · 1991 · 359 citations

Pharmaceutical Science, Pharmacotherapy, Pharmaceutical Chemistry +20

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

A.L. Jackman, Rosemary Kimbell, Melody Brown et al. · British Journal of Cancer · 1995 · 102 citations · Full text

Natural Sciences, Molecular Biology, Resistance Mutation (Virology) +5

Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors

Peter R. Marsham, J. Michael Wardleworth, F. Thomas Boyle et al. · Journal of Medicinal Chemistry · 1999 · 46 citations · Full text

Combinatorial Chemistry, Organic Chemistry, Pharmacotherapy +16

A system for determining the pharmacology of indirect radiation sensitizer drugs on multicellular spheroids.

Nathan Kaufman, Haim I. Bicher, Fred W. Hetzel et al. · PubMed · 1981 · 20 citations

Radiation Exposure, Radiation Biology, Redox Biology +16

Substituted-2-Desamino-2-Methyl-Quinazolinones. A Series of Novel Antitumour Agents

F.T. Boyle, Zbigniew S. Matusiak, L. R. HUGHES et al. · Advances in experimental medicine and biology · 1993 · 11 citations

Molecular Pharmacology, Medicinal Chemistry, Medicine +6