Rosemary Kimbell

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

A.L. Jackman, G A Taylor, William Gibson et al. · PubMed · 1991 · 359 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

A.L. Jackman, Rosemary Kimbell, Melody Brown et al. · British Journal of Cancer · 1995 · 102 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +3

Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.

Ann L. Jackman, Rosemary Kimbell, G. Wynne Aherne et al. · PubMed · 1997 · 92 citations

Medicine, Oncology, Pharmacology +13

Design and Synthesis of Cyclopenta[<i>g</i>]quinazoline-Based Antifolates as Inhibitors of Thymidylate Synthase and Potential Antitumor Agents^,

Vassilios Bavetsias, Jonathan H. Marriott, Camille Melin et al. · Journal of Medicinal Chemistry · 2000 · 91 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors

Peter R. Marsham, J. Michael Wardleworth, F. Thomas Boyle et al. · Journal of Medicinal Chemistry · 1999 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11