Ann L. Jackman

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

Terence R. Jones, A H Calvert, Ann L. Jackman et al. · European Journal of Cancer (1965) · 1981 · 239 citations

Antiparasitic Agent, Medicine, Molecular Biology +8

bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

Thomas C. Fisher, Anne E. Milner, C D Gregory et al. · PubMed · 1993 · 237 citations

Immunotoxicology, Chemoprevention Strategy, Apoptosis +21

Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation

D. Mark Pritchard, Alastair J.M. Watson, Christopher S. Potten et al. · Proceedings of the National Academy of Sciences · 1997 · 198 citations · Full text

Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

Joost W van der Heijden, Ruud Oerlemans, Ben A. C. Dijkmans et al. · Arthritis & Rheumatism · 2008 · 153 citations

Targeting the α-folate receptor with cyclopenta[g]quinazoline-based inhibitors of thymidylate synthase

Elisa Henderson, Vassilios Bavetsias, Davinder S. Theti et al. · Bioorganic & Medicinal Chemistry · 2006 · 135 citations

Molecular Pharmacology, Drug Target, Drug Targeting +8