L. R. HUGHES - Concepedia

Author

L. R. HUGHES

Institute of Cancer Research

Also Known As

L R Hughes, L. R. HUGHES, L. R. Hughes, L.R. Hughes, LR Hughes, Leslie R. Hughes, Liam Hughes, Lois Hughes

Publications

474

Citations

H-Index

Concepts

All Affiliations

Institute of Cancer Research AstraZeneca (United Kingdom)

About

L. R. HUGHES is an author at Institute of Cancer Research specializing in pharmacology, medicine, and medicinal chemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	5	5	189
2	Natural Sciences	1	1	70
3	Biochemistry	1	1	70
4	Chemistry	1	1	70
5	Endocrinology	1	1	86

L. R. HUGHES

Publications

390

Citations

H-Index

Page 1

	Year	Citations
Receptor binding and biological activity of steroidal and nonsteroidal antiandrogens A. E. Wakeling, B.J.A. Furr, Angela Glen, Journal of Steroid Biochemistry Endocrine MechanismMedicineHormonal ReceptorAromataseReceptor Binding	1981	86
Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors. Stephen Clarke, Janet Hanwell, M. de Boer, Journal of Clinical Oncology	1996	74
Non-steroidal antiandrogens. Design of novel compounds based on an infrared study of the dominant conformation and hydrogen-bonding properties of a series of anilide antiandrogens Jeffrey J. Morris, L. R. HUGHES Journal of Medicinal Chemistry Bioorganic ChemistryOrganic ChemistryChemistryPharmaceutical ChemistryChemical Derivative	1991	70
Thymidylate synthase: A target for anticancer drug design K.R. Harrap, Ann L. Jackman, David R. Newell, Advances in Enzyme Regulation MedicineSynthetic BiologyThymidylate SynthaseAnti-cancer AgentDrug Development	1989	51
Synthesis of the antileukaemic lignan precursor (±) steganone L. R. HUGHES, R. A. Raphael Tetrahedron Letters Medicinal ChemistryAntileukaemic Lignan PrecursorOrganic ChemistryPharmacologyPharmaceutical Chemistry	1976	31
The pharmacokinetics of the quinazoline antifolate ICID 1694 in mice and rats DI Jodrell, David R. Newell, William Gibson, Cancer Chemotherapy and Pharmacology Pharmacological StudyMedicineExperimental PharmacologyPharmacotherapyPharmacology	1991	28
The Synthesis and Thymidylate Synthase Inhibitory Activity of L-.gamma.-L-Linked Dipeptide and L-.gamma.-Amide Analogs of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) Graham M. F. Bisset, Vassilios Bavetsias, T. J. Thornton, Journal of Medicinal Chemistry	1994	16
Estimation of the In Vitro and In Vivo Inhibitory Effects of Antifolates upon Thymidylate Synthase (TS) in Whole Cells Geoffrey A. Taylor, A L Jackman, Kathryn Balmanno, Advances in experimental medicine and biology MedicineImmunologyThymidylate SynthaseWhole CellsThyroid Hormone	1989	13
Substituted-2-Desamino-2-Methyl-Quinazolinones. A Series of Novel Antitumour Agents F.T. Boyle, Zbigniew S. Matusiak, L. R. HUGHES, Advances in experimental medicine and biology Molecular PharmacologyMedicinal ChemistryMedicineNovel Antitumour AgentsPharmacotherapy	1993	11
Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation. Ann L. Jackman, Rosemary Kimbell, Melody Brown, PubMed	1995	10

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