L. R. HUGHES

Receptor binding and biological activity of steroidal and nonsteroidal antiandrogens

A. E. Wakeling, B.J.A. Furr, Angela Glen et al. · Journal of Steroid Biochemistry · 1981 · 86 citations

Endocrine Mechanism, Medicine, Hormonal Receptor +5

Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors.

Stephen Clarke, Janet Hanwell, M. de Boer et al. · Journal of Clinical Oncology · 1996 · 74 citations

Non-steroidal antiandrogens. Design of novel compounds based on an infrared study of the dominant conformation and hydrogen-bonding properties of a series of anilide antiandrogens

Jeffrey J. Morris, L. R. HUGHES · Journal of Medicinal Chemistry · 1991 · 70 citations

Bioorganic Chemistry, Organic Chemistry, Chemistry +17

Thymidylate synthase: A target for anticancer drug design

K.R. Harrap, Ann L. Jackman, David R. Newell et al. · Advances in Enzyme Regulation · 1989 · 51 citations

Medicine, Synthetic Biology, Thymidylate Synthase +4

Synthesis of the antileukaemic lignan precursor (±) steganone

L. R. HUGHES, R. A. Raphael · Tetrahedron Letters · 1976 · 31 citations

Medicinal Chemistry, Antileukaemic Lignan Precursor, Organic Chemistry +4