Concepedia

Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate

David A. Matthews, J. Ernest Villafranca, Cheryl A. Janson, Ward W. Smith, Katherine M. Welsh, S. Freer

Journal of Molecular Biology · 1990 · 117 citations · 32 references

DOI

Concepts

References

32

Resolution of phase ambiguity in macromolecular crystallography

Bi‐Cheng Wang · Methods in enzymology on CD-ROM/Methods in enzymology · 1985 · 1K citations

, , +14

The Kinetics of Cellular Proliferation

The Medical Journal of Australia · 1960 · 954 citations

, , +9

Analysis of the relationship between side-chain conformation and secondary structure in globular proteins

Malcolm J. McGregor, Suhail A. Islam, Michael J.E. Sternberg · Journal of Molecular Biology · 1987 · 422 citations

, , +16

Crystallographic refinement by simulated annealing

Axel T. Brünger · Journal of Molecular Biology · 1988 · 406 citations

, , +16

Functional Role of Aspartic Acid-27 in Dihydrofolate Reductase Revealed by Mutagenesis

Elizabeth E. Howell, J. Ernest Villafranca, Mark S. Warren et al. · Science · 1986 · 230 citations

, , +17