Concepedia

Synthesis and Evaluation of 2,6-Modified Purine 2′-<i>C</i>-Methyl Ribonucleosides as Inhibitors of HCV Replication

Longhu Zhou, Hongwang Zhang, Sijia Tao, Maryam Ehteshami, Jong Hyun Cho, Tamara R. McBrayer, Philip Tharnish, Tony Whitaker, Franck Amblard, Steven J. Coats,

ACS Medicinal Chemistry Letters · 2015 · 19 citations · 15 references

DOI

Concepts

Abstract

A variety of 2,6-modified purine 2'-C-methylribonucleosides and their phosphoramidate prodrugs were synthesized and evaluated for inhibition of HCV RNA replication in Huh-7 cells and for cytotoxicity in various cell lines. Cellular pharmacology and HCV polymerase incorporation studies on the most potent and selective compound are reported.

References

15

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Lieven Stuyver, Tony Whitaker, Tamara R. McBrayer et al. · Antimicrobial Agents and Chemotherapy · 2002 · 202 citations · Full text

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Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

Anne B. Eldrup, Charles Allerson, C. Frank Bennett et al. · Journal of Medicinal Chemistry · 2004 · 187 citations · Full text

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Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1

Raymond F. Schinazi, J P Sommadossi, Vanessa Saalmann et al. · Antimicrobial Agents and Chemotherapy · 1990 · 173 citations · Full text

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