Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Dirk Jochmans, Jérôme Deval, Bart Kesteleyn, +11

Journal of Virology

Characterization of β- <scp>d</scp> - <i>N</i> ⁴ -Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

Maryam Ehteshami, Sijia Tao, Keivan Zandi, +7

Antimicrobial Agents and Chemotherapy

Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms

Maryam Ehteshami, Greg L. Beilhartz, Brian J. Scarth, +5

Journal of Biological Chemistry

Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity

Michaela Wendeler, Hsiu-Fang Lee, Alun Bermingham, +10

ACS Chemical Biology

Bioorganic ChemistryMolecular BiologyAntiviral DrugChemical BiologyProtein Synthesis +15

All‐oral, interferon‐free treatment for chronic hepatitis <scp>C</scp>: cost‐effectiveness analyses

Liesl M. Hagan, Zhuo Yang, Maryam Ehteshami, +1

Journal of Viral Hepatitis

Mutations M184V and Y115F in HIV-1 Reverse Transcriptase Discriminate against “Nucleotide-competing Reverse Transcriptase Inhibitors”

Maryam Ehteshami, Brian J. Scarth, Egor P. Tchesnokov, +5

Journal of Biological Chemistry

HIV‐1 Reverse Transcriptase Connection Domain Mutations: Dynamics of Emergence and Implications for Success of Combination Antiretroviral Therapy

Viktor von Wyl, Maryam Ehteshami, Lisa M. Demeter, +10

Clinical Infectious Diseases

Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV-1 Reverse Transcriptase on DNA–DNA Substrates at the Single-Molecule Level

Ryan A. Marko, Hsiao-Wei Liu, Christopher J. Ablenas, +3

The Journal of Physical Chemistry B

β-<scp>d</scp>-2′-<i>C</i>-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5′-Triphosphate Forms

Longhu Zhou, Hongwang Zhang, Sijia Tao, +12

Journal of Medicinal Chemistry

Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility.

Maryam Ehteshami, Matthias Götte

PubMed

Viral ReplicationDrug SusceptibilityHuman RetrovirusRnase H DomainsImmunology +13