Jérôme Deval

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor <i>In Vitro</i> and Confer Resistance To Nirmatrelvir

Dirk Jochmans, Kim Donckers, Antitsa Stoycheva et al. · mBio · 2023 · 170 citations · Full text

Life Sciences, Infectious Diseases, Pharmacology +16

Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Dirk Jochmans, Jérôme Deval, Bart Kesteleyn et al. · Journal of Virology · 2006 · 94 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development

Cheng Liu, Sandro Boland, Michael D. Scholle et al. · Antiviral Research · 2021 · 56 citations · Full text

Life Sciences, Infectious Diseases, Medicinal Chemistry +16

Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs

Zhinan Jin, April Kinkade, Ishani Behera et al. · Antiviral Research · 2017 · 47 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′-<i>C</i>-methyluridine 5′-Phosphoramidate Prodrug (<b>AL-335</b>) for the Treatment of Hepatitis C Infection

Guangyi Wang, Natalia Dyatkina, Marija Prhavc et al. · Journal of Medicinal Chemistry · 2019 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17