Natalia Dyatkina

Targeted gene knockout mediated by triple helix forming oligonucleotides

Alokes Majumdar, Alexander Khorlin, Natalia Dyatkina et al. · Nature Genetics · 1998 · 149 citations

Natural Sciences, Oligonucleotide, Molecular Biology +6

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-<i>O</i>-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Guangyi Wang, Jérôme Deval, Jin Tae Hong et al. · Journal of Medicinal Chemistry · 2015 · 128 citations

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine <i>C</i>-Nucleosides as Favipiravir (T-705) Analogues

Guangyi Wang, Jinqiao Wan, Yujian Hu et al. · Journal of Medicinal Chemistry · 2016 · 91 citations

Compound 3C, Medicinal Chemistry, Anti-influenza Activity +12

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Jérôme Deval, Jin Tae Hong, Guangyi Wang et al. · PLoS Pathogens · 2015 · 90 citations · Full text

Selective Inhibition, Viral Replication, Molecular Virology +15

Efficiency of Incorporation and Chain Termination Determines the Inhibition Potency of 2′-Modified Nucleotide Analogs against Hepatitis C Virus Polymerase

Amy Fung, Zhinan Jin, Natalia Dyatkina et al. · Antimicrobial Agents and Chemotherapy · 2014 · 82 citations · Full text

Viral Replication, Viral Polymerase Structure, 2′-Modified Nucleotide Analogs +16