Guangyi Wang

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-<i>O</i>-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Guangyi Wang, Jérôme Deval, Jin Tae Hong et al. · Journal of Medicinal Chemistry · 2015 · 138 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Jérôme Deval, Jin Tae Hong, Guangyi Wang et al. · PLoS Pathogens · 2015 · 95 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine <i>C</i>-Nucleosides as Favipiravir (T-705) Analogues

Guangyi Wang, Jinqiao Wan, Yujian Hu et al. · Journal of Medicinal Chemistry · 2016 · 92 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Efficiency of Incorporation and Chain Termination Determines the Inhibition Potency of 2′-Modified Nucleotide Analogs against Hepatitis C Virus Polymerase

Amy Fung, Zhinan Jin, Natalia Dyatkina et al. · Antimicrobial Agents and Chemotherapy · 2014 · 83 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2′- <i>C</i> -Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases

Zhinan Jin, Kathryn Tucker, Xiaoyan Lin et al. · Antimicrobial Agents and Chemotherapy · 2015 · 67 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +17