Small-Molecule Inhibition of TNF-α

Molly M. He, Annemarie Stroustrup, Johan D. Oslob, +17

Science

ImmunologyCell DeathMolecular BiologyInflammationTnf-alpha Subunits +15

Structure of the Respiratory Syncytial Virus Polymerase Complex

Morgan S. A. Gilman, Cheng Liu, Amy Fung, +12

Cell

Virus StructureViral ReplicationViral Polymerase StructureMolecular BiologyVirology +3

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-<i>O</i>-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Guangyi Wang, Jérôme Deval, Jin Tae Hong, +15

Journal of Medicinal Chemistry

Discovery of a potent and selective Aurora kinase inhibitor

Johan D. Oslob, M.J. Romanowski, Darin A. Allen, +25

Bioorganic & Medicinal Chemistry Letters

Signaling PathwayReceptor Tyrosine KinaseMedicineCell BiologyCell Signaling +2

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Jérôme Deval, Jin Tae Hong, Guangyi Wang, +20

PLoS Pathogens

Selective InhibitionViral ReplicationMolecular VirologyBiochemistryMedicine +13

Efficiency of Incorporation and Chain Termination Determines the Inhibition Potency of 2′-Modified Nucleotide Analogs against Hepatitis C Virus Polymerase

Amy Fung, Zhinan Jin, Natalia Dyatkina, +3

Antimicrobial Agents and Chemotherapy

Viral ReplicationViral Polymerase Structure2′-Modified Nucleotide AnalogsMolecular BiologyAntiviral Drug +14

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

Laura Silvian, Jessica E. Friedman, Kathy Strauch, +6

ACS Chemical Biology

Protein AssemblyImmune RegulationImmunologyCell DeathMolecular Biology +27

A Conserved Domain of <i>Schizosaccharomyces pombe dfp1</i> ⁺ Is Uniquely Required for Chromosome Stability following Alkylation Damage during S Phase

Amy Fung, Jiongwen Ou, Stephanie A. Bueler, +1

Molecular and Cellular Biology

Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′-<i>C</i>-methyluridine 5′-Phosphoramidate Prodrug (<b>AL-335</b>) for the Treatment of Hepatitis C Infection

Guangyi Wang, Natalia Dyatkina, Marija Prhavc, +18

Journal of Medicinal Chemistry

2-Aminobenzimidazoles as potent Aurora kinase inhibitors

Min Zhong, Minna Bui, Shen Wang, +26

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacotherapyAnti-cancer AgentPharmacology +3