N+1 Engineering of an Aspartate Isomerization Hotspot in the Complementarity-Determining Region of a Monoclonal Antibody

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

Terrence L. Geiger, Steven Clarke · Journal of Biological Chemistry · 1987 · 1.3K citations · Full text

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Molecular clocks

Noah E. Robinson, Arthur B. Robinson · Proceedings of the National Academy of Sciences · 2001 · 538 citations · Full text

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A Conformational Flexibility Scale for Amino Acids in Peptides

Fang Huang, Werner M. Nau · Angewandte Chemie International Edition · 2003 · 219 citations · Full text

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Isomerization of an Aspartic Acid Residue in the Complementarity-Determining Regions of a Recombinant Antibody to Human IgE:  Identification and Effect on Binding Affinity

Jerry Cacia, Rodney G. Keck, Leonard G. Presta et al. · Biochemistry · 1996 · 199 citations

Pharmacy, Biochemistry, Immunology +17

Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions

Quanzhou Luo, Marisa K. Joubert, Riki Stevenson et al. · Journal of Biological Chemistry · 2011 · 198 citations · Full text

Life Sciences, Biochemistry, Chemistry +17