Concepedia

Complementarity-determining Region (Cdr) Optimization

Complementarity-Determining Region (CDR) Optimization is a computational and experimental refinement process within antibody humanization that specifically enhances the antigen-binding affinity and specificity of humanized antibodies by strategically modifying the amino acid residues in the complementarity-determining regions while preserving their structural integrity and immunological function.

104

Publications

8K

Citations

724

Authors

181

Institutions

Publications per year

2017–2026

43

Parents

Publications

104

Replacing the complementarity-determining regions in a human antibody with those from a mouse

Peter Jones, Paul H. Dear, Jefferson Foote et al. · Nature · 1986 · 1.4K citations

, , +13

Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

Robert Schier, Adrian M. McCall, Gregory P. Adams et al. · Journal of Molecular Biology · 1996 · 383 citations

, , +16

Five computational developability guidelines for therapeutic antibody profiling

Matthew I. J. Raybould, Claire Marks, Konrad Krawczyk et al. · Proceedings of the National Academy of Sciences · 2019 · 368 citations · Full text

, , +17

VIPER: Visualization Pipeline for RNA-seq, a Snakemake workflow for efficient and complete RNA-seq analysis

MacIntosh Cornwell, Mahesh Vangala, Len Taing et al. · BMC Bioinformatics · 2018 · 232 citations · Full text

, , +14

In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity.

Carlos F. Barbas, Dana D. Hu, Nancy M. Dunlop et al. · Proceedings of the National Academy of Sciences · 1994 · 216 citations · Full text

, , +17

1–5 of 104

Authors

724

  1. PM
    Peter M. Tessier

    Rensselaer Polytechnic Institute, United States

    6 publications · 345 citations

    6

    h-index

  2. AA
    Alexey A. Lugovskoy

    Biogen (United States), United States

    3 publications · 83 citations

    3

    h-index

  3. KE
    Kathryn E. Tiller

    Rensselaer Polytechnic Institute, United States

    3 publications · 146 citations

    3

    h-index

  4. SV
    S. V. S. Kashmiri

    National Cancer Institute, United States

    3 publications · 107 citations

    3

    h-index

  5. HS
    Hans Söderlund

    University of Helsinki, Finland

    3 publications · 124 citations

    3

    h-index

1–5 of 724

Institutions

181

  1. Rensselaer Polytechnic Institute

    Troy, United States

    6 h-index

    27 publications

    1.5K citations

  2. National Cancer Institute

    Bethesda, United States

    5 h-index

    14 publications

    698 citations

  3. National Institutes of Health

    Bethesda, United States

    5 h-index

    17 publications

    732 citations

  4. Eli Lilly (United States)

    Indianapolis, United States

    4 h-index

    21 publications

    1.7K citations

  5. University of California, San Francisco

    San Francisco, United States

    4 h-index

    35 publications

    3.9K citations

  6. Scripps Research Institute

    San Diego, United States

    3 h-index

    16 publications

    2.3K citations

  7. Sichuan University

    Chengdu, China

    3 h-index

    10 publications

    664 citations

  8. Pfizer (United States)

    New York, United States

    3 h-index

    12 publications

    728 citations

1–8 of 181

Venues

  1. mAbs

    12 publications · 590 citations

    12

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 9 publications · 663 citations

    9

    h-index

  3. Journal of Biological Chemistry

    JBC · 7 publications · 250 citations

    7

    h-index

  4. Molecular Immunology

    6 publications · 215 citations

    6

    h-index

  5. The Journal of Immunology

    JI · 5 publications · 377 citations

    5

    h-index

1–5