Concepedia

Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

Robert Schier, Adrian M. McCall, Gregory P. Adams, Keith W. Marshall, Hanne Merritt, Michael T. Yim, Robert S. Crawford, Louis M. Weiner, Cara Marks, James D. Marks

Journal of Molecular Biology · 1996 · 383 citations · 0 references

Concepts

PharmacyBiochemistryMolecular BiologyAntibody EngineeringMonoclonal AntibodiesStructural BiologyAntibody CharacterizationAntibody DiscoveryAntibody Fragment EngineeringAntibody PurificationAntibody StructureAntibody-antigen RecognitionAntibody Binding SpecificityAntigen-antibody RecognitionAntigen-binding Site DesignAntigen-binding Site StructureComplementarity-determining Region (Cdr) OptimizationComplementarity-determining Region AnalysisComplementarity-determining Region Diversity