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Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

Immunocytochemical TechniqueComplementarity Determining RegionsImmunologyMolecular BiologyAntibody ScreeningAntibody EngineeringImmunoglobulin EImmunotherapyMedicineAntibody Binding Site