Robert Schier

High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.

Gregory P. Adams, Robert Schier, Adrian M. McCall et al. · PubMed · 2001 · 624 citations

Pharmacy, Oncology, Pharmacology +17

Efficient construction of a large nonimmune phage antibody library: The production of high-affinity human single-chain antibodies to protein antigens

Michael Sheets, Peter Amersdorfer, Ricarda Finnern et al. · Proceedings of the National Academy of Sciences · 1998 · 440 citations

Pharmacy, Biochemistry, Immunology +17

Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

Robert Schier, Adrian M. McCall, Gregory P. Adams et al. · Journal of Molecular Biology · 1996 · 383 citations

Pharmacy, Biochemistry, Molecular Biology +16

Isolation of High-affinity Monomeric Human Anti-c-erbB-2 Single chain Fv Using Affinity-driven Selection

Robert Schier, Jacqueline M. Bye, Gerald Apell et al. · Journal of Molecular Biology · 1996 · 294 citations

Engineering, Molecular Biology, Immunotechnology +7

Increased affinity leads to improved selective tumor delivery of single-chain Fv antibodies.

Gregory P. Adams, Robert Schier, Katherine L. Marshall et al. · PubMed · 1998 · 231 citations

Medicine, Cancer Biology, Oncology +16