Concepedia

Complementarity-determining Region Diversity

Complementarity-Determining Region Diversity is a molecular immunological construct that quantifies the variability within the antigen-binding sites of immunoglobulin or T-cell receptor molecules, specifically distinguishing the sequence and structural heterogeneity of hypervariable loops responsible for epitope recognition.

152

Publications

11.1K

Citations

850

Authors

261

Institutions

Publications per year

2017–2026

28

Variants

Cdr Diversity

Parents

Publications

152

Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities

Mark M. Davis · Immunity · 2000 · 804 citations · Full text

, , +16

CDR3 length in antigen-specific immune receptors.

Edwin P. Rock, Peter R. Sibbald, Mark M. Davis et al. · The Journal of Experimental Medicine · 1994 · 513 citations · Full text

, , +17

Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing

Jamie Freeman, John R. Webb, Brad H. Nelson et al. · Genome Research · 2009 · 415 citations · Full text

, , +17

Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

Robert Schier, Adrian M. McCall, Gregory P. Adams et al. · Journal of Molecular Biology · 1996 · 383 citations

, , +16

Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem.

Carlos F. Barbas, Jim D. Bain, Denise Hoekstra et al. · Proceedings of the National Academy of Sciences · 1992 · 374 citations

, , +17

1–5 of 152

Authors

850

  1. EA
    Elvin A. Kabat

    Columbia University, United States

    4 publications · 279 citations

    4

    h-index

  2. JC
    Juan C. Almagro

    Universidad Nacional Autónoma de México, Mexico

    3 publications · 130 citations

    3

    h-index

  3. SR
    Stuart Rudikoff

    National Cancer Institute, United States

    3 publications · 145 citations

    3

    h-index

  4. MN
    M Nei

    Pennsylvania State University, United States

    3 publications · 282 citations

    3

    h-index

  5. YD
    Yong Dai

    Jinan University, China

    3 publications · 51 citations

    3

    h-index

1–5 of 850

Institutions

261

  1. National Institutes of Health

    Bethesda, United States

    8 h-index

    34 publications

    2K citations

  2. National Cancer Institute

    Bethesda, United States

    6 h-index

    19 publications

    1.5K citations

  3. Scripps Research Institute

    San Diego, United States

    5 h-index

    22 publications

    2K citations

  4. New York University

    New York, United States

    4 h-index

    7 publications

    122 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    14 publications

    937 citations

  6. Stanford University

    Stanford, United States

    4 h-index

    16 publications

    4.9K citations

  7. Cornell University

    Ithaca, United States

    4 h-index

    20 publications

    2.8K citations

  8. Institut Pasteur

    Paris, France

    4 h-index

    12 publications

    1.5K citations

1–8 of 261

Venues

  1. The Journal of Immunology

    JI · 37 publications · 2.1K citations

    26

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 21 publications · 2.1K citations

    20

    h-index

  3. International Immunology

    6 publications · 205 citations

    6

    h-index

  4. mAbs

    6 publications · 241 citations

    6

    h-index

  5. Journal of Virology

    JVI · 5 publications · 144 citations

    5

    h-index

1–5