Concepedia

Equilibrium and kinetic selectivity profiling on the human adenosine receptors

Dong Guo, Gabrielle S. Dijksteel, Tirsa T van Duijl, Maxime R. Heezen, Laura H. Heitman, Adriaan P. IJzerman

Biochemical Pharmacology · 2016 · 23 citations · 14 references

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Concepts

References

14

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

The kinetics of competitive radioligand binding predicted by the law of mass action.

Harvey Motulsky, L C Mahan · Molecular Pharmacology · 1984 · 419 citations

, , +17

Functional efficacy of adenosine A<sub>2A</sub>receptor agonists is positively correlated to their receptor residence time

Dong Guo, Thea Mulder‐Krieger, Adriaan P. IJzerman et al. · British Journal of Pharmacology · 2012 · 185 citations · Full text

, , +17

Assessing the distribution of parameters in models of ligand–receptor interaction: to log or not to log

Arthur Christopoulos · Trends in Pharmacological Sciences · 1998 · 181 citations

, , +12

Slow receptor dissociation is not a key factor in the duration of action of inhaled long‐acting β <sub>2</sub> ‐adrenoceptor agonists

David A. Sykes, Steven J. Charlton · British Journal of Pharmacology · 2012 · 75 citations · Full text

, , +17