Steven J. Charlton

The role of kinetic context in apparent biased agonism at GPCRs

Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti et al. · Nature Communications · 2016 · 337 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

Jamie McPherson, Guadalupe Rivero, Myma Baptist et al. · Molecular Pharmacology · 2010 · 268 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

David A. Sykes, Holly Moore, Lisa A. Stott et al. · Nature Communications · 2017 · 224 citations · Full text

Medicine, Neuroscience, Pharmacology +17

In Vitro and in Vivo Pharmacological Characterization of 5-[(R)-2-(5,6-Diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1 H-quinolin-2-one (Indacaterol), a Novel Inhaled β2 Adrenoceptor Agonist with a 24-h Duration of Action

Cliff H. Battram, Steven J. Charlton, Bernard Cuenoud et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 162 citations

Medicine, Medicinal Chemistry, Pharmacology +12

The M ₃ -muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner

Benoit Poulin, Adrian J. Butcher, Phillip McWilliams et al. · Proceedings of the National Academy of Sciences · 2010 · 144 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17