μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Operational models of pharmacological agonism

J.W. Black, P. Leff · Proceedings of the Royal Society of London. Series B, Biological sciences · 1983 · 1.1K citations

Medicine, Pharmacology, General Pharmacology +16

Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

Candace B. Pert, Gavril W. Pasternak, Solomon H. Snyder · Science · 1973 · 545 citations

Medicine, Neurobiology, Pharmacology +17

COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS*

Robert F. Furchgott, Paula Bursztyn · Annals of the New York Academy of Sciences · 1967 · 528 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

John R. Traynor, Stefan R. Nahorski · Molecular Pharmacology · 1995 · 462 citations

Life Sciences, Biochemistry, Pharmacology +17