Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

Whole genomes redefine the mutational landscape of pancreatic cancer

Nicola Waddell, Marina Pajic, Ann‐Marie Patch et al. · Nature · 2015 · 2.7K citations · Full text

Medicine, Genetics, Oncology +15

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Cory M. Johannessen, Jesse S. Boehm, So Young Kim et al. · Nature · 2010 · 1.4K citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +14

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

Jessie Villanueva, Adina Vultur, John Tayu Lee et al. · Cancer Cell · 2010 · 1.2K citations · Full text

Medicine, Cancer Biology, Oncology +13

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

Anurag Singh, Patricia Greninger, Daniel R. Rhodes et al. · Cancer Cell · 2009 · 864 citations · Full text

Medicine, Cancer Biology, Molecular Biology +14

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

Elizabeth S. Yeh, Melissa Cunningham, Hugh Arnold et al. · Nature Cell Biology · 2004 · 791 citations

Medicine, Cell Biology, Molecular Biology +16