Prson Gautam

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

Tikvah K. Hayes, Nicole F. Neel, Chaoxin Hu et al. · Cancer Cell · 2015 · 271 citations · Full text

Oncology, Pancreatic Cancer, Long-term Erk Inhibition +10

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Laura Hakanpää, Tuomas Sipilä, Veli‐Matti Leppänen et al. · Nature Communications · 2015 · 266 citations · Full text

Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

G. Aaron Hobbs, Nicole M. Baker, Anne M. Miermont et al. · Cancer Discovery · 2019 · 210 citations · Full text

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

Angelina V. Vaseva, Devon R. Blake, Thomas S.K. Gilbert et al. · Cancer Cell · 2018 · 186 citations · Full text

Reductive Stress, Signal Transduction, Biochemistry +13

Prediction of drug combination effects with a minimal set of experiments

Aleksandr Ianevski, Anil K. Giri, Prson Gautam et al. · Nature Machine Intelligence · 2019 · 176 citations · Full text

Pharmacokinetic Modeling, Minimal Set, Drug Discovery +10