New England Journal of Medicine · 2015 · 329 citations · 3 references
MedicineGeneticsOncologyCancer GeneticsCarcinogenesisMolecular OncologyCancer EtiologyCancer GenomicsCancer ProgressionMalignant NeoplasmsNeoplastic TransformationOncogenic Signaling PathwaysCancer Signaling PathwaysDriver Mutation DiscoveryDriver Mutation DiversityDriver Mutation IdentificationDriver Oncogene IdentificationMolecular Mechanisms Of CarcinogenesisOncogenic Driver MutationsTarget Gene Mutations
Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults, alterations in as few as three driver genes appear to suffice for a cell to evolve into an advanced cancer.
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