Concepedia

Surface-bound TGF-beta1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusions.

Junji Wada, Hideya Onishi, Hiroyuki Suzuki, Akio Yamasaki, Shuntaro Nagai, Takashi Morisaki, Mitsuo Katano

PubMed · 2010 · 79 citations · 33 references

Abstract

Elimination of Eff-Ex or control of Eff-Ex expressing TGF-β1 may be new therapeutic strategies in immunotherapy for advanced cancer patients with malignant effusions.

References

33

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science · 2003 · 8K citations

Lymphocyte Development, Genetics, T-regulatory Cell +24

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot, Marc A. Gavin, Alexander Y. Rudensky · Nature Immunology · 2003 · 7.6K citations

Lymphocyte Development, T-regulatory Cell, Immunology +9

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Tyler J. Curiel, George Coukos, Linhua Zou et al. · Nature Medicine · 2004 · 5K citations

Cancer Immunosurveillance, Specific Recruitment, T-regulatory Cell +9

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor <i>Foxp3 </i>

WanJun Chen, Wenwen Jin, Neil J. Hardegen et al. · The Journal of Experimental Medicine · 2003 · 4.6K citations · Full text

T-regulatory Cell, Immune Regulation, Immunology +18

B lymphocytes secrete antigen-presenting vesicles.

Graça Raposo, Hans W. Nijman, Willem Stoorvogel et al. · The Journal of Experimental Medicine · 1996 · 3.4K citations · Full text

Protein Secretion, Secrete Antigen-presenting Vesicles, Humoral Response +20