Intratumoral CD8+ T/FOXP3+ cell ratio is a predictive marker for survival in patients with colorectal cancer

Hiroyuki Suzuki, Nobuhito Chikazawa, Takehiko Tasaka, +8

Cancer Immunology Immunotherapy

Gastrointestinal OncologyMedicineImmunologyColorectal CancerPathology +4

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway

Mio Ikebe, Yoshiki Kitaura, Masafumi Nakamura, +11

Journal of Surgical Oncology

The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions.

Junji Wada, Hiroyuki Suzuki, Ryouta Fuchino, +8

PubMed

Dendritic CellT-regulatory CellImmune RegulationImmunologyPathology +15

VEGFR2 is selectively expressed by FOXP3^high CD4⁺ Treg

Hiroyuki Suzuki, Hideya Onishi, Junji Wada, +5

European Journal of Immunology

T-regulatory CellImmunologyRegulatory T CellsHigh-level ExpressionImmunotherapy +18

Surface-bound TGF-beta1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusions.

Junji Wada, Hideya Onishi, Hiroyuki Suzuki, +4

PubMed

Oestrogen receptor-α contributes to the regulation of the hedgehog signalling pathway in ERα-positive gastric cancer

Chizu Kameda, Masafumi Nakamura, Hirofumi Tanaka, +5

British Journal of Cancer

The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer.

Chizu Kameda, Haruo Tanaka, Akio Yamasaki, +7

PubMed

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

Akio Yamasaki, Chizu Kameda, Rui Xu, +9

Cancer Immunology Immunotherapy

Cancer ResearchPancreatic CancerMedicineImmunologyPancreatic Cancer Progression +5

Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer

Hideya Onishi, Akio Yamasaki, Makoto Kawamoto, +2

Cancer Letters

Mastermind-like 3Pancreatic CancerMedicinePathologyCancer Cell Biology +6

Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes

Hideya Onishi, Akiko Fujimura, Yasuhiro Oyama, +6

Cellular Immunology

Cancer ResearchCancer ImmunosurveillanceCell RegulationPdl-1 ExpressionImmunology +10