Intratumoral CD8+ T/FOXP3+ cell ratio is a predictive marker for survival in patients with colorectal cancer

Hiroyuki Suzuki, Nobuhito Chikazawa, Takehiko Tasaka, +8

Cancer Immunology Immunotherapy

Gastrointestinal OncologyMedicineImmunologyColorectal CancerPathology +4

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway

Mio Ikebe, Yoshiki Kitaura, Masafumi Nakamura, +11

Journal of Surgical Oncology

The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions.

Junji Wada, Hiroyuki Suzuki, Ryouta Fuchino, +8

PubMed

Dendritic CellT-regulatory CellImmune RegulationImmunologyPathology +15

VEGFR2 is selectively expressed by FOXP3^high CD4⁺ Treg

Hiroyuki Suzuki, Hideya Onishi, Junji Wada, +5

European Journal of Immunology

T-regulatory CellImmunologyRegulatory T CellsHigh-level ExpressionImmunotherapy +18

γ-Secretase Inhibitors Enhance Taxane-Induced Mitotic Arrest and Apoptosis in Colon Cancer Cells

Takashi Akiyoshi, Masafumi Nakamura, Kosuke Yanai, +7

Gastroenterology

MedicineColon Cancer CellsCancer Cell BiologyCell DeathColorectal Cancer +7

Surface-bound TGF-beta1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusions.

Junji Wada, Hideya Onishi, Hiroyuki Suzuki, +4

PubMed

<i>Gli1</i>contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase‐9 activation

Shuntaro Nagai, Masafumi Nakamura, Kosuke Yanai, +7

Cancer Science

PathologyCancer BiologyTumor BiologyHh PathwayPancreatic Cancer +14

Crosstalk of hedgehog and Wnt pathways in gastric cancer

Kosuke Yanai, Masafumi Nakamura, Takashi Akiyoshi, +8

Cancer Letters

Gastrointestinal OncologyMedicinePathologyGastric CancerOncology +2

Enhancement of paclitaxel-induced apoptosis by inhibition of mitogen-activated protein kinase pathway in colon cancer cells.

Rui Xu, Norihiro Sato, Kosuke Yanai, +7

PubMed

Mapk InhibitionPaclitaxel-induced ApoptosisMedicineColon Cancer CellsApoptosis +12

Hedgehog signaling pathway is a possible therapeutic target for gastric cancer

Kosuke Yanai, Shuntaro Nagai, Junji Wada, +7

Journal of Surgical Oncology