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γ-Secretase Inhibitors Enhance Taxane-Induced Mitotic Arrest and Apoptosis in Colon Cancer Cells

Takashi Akiyoshi, Masafumi Nakamura, Kosuke Yanai, Shuntaro Nagai, Junji Wada, Kenichiro Koga, Hiroshi Nakashima, Norihiro Sato, Masao Tanaka, Mitsuo Katano

Gastroenterology · 2007 · 89 citations · 25 references

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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

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Genetic instability in colorectal cancers

Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein · Nature · 1997 · 2K citations

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Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Johan H. van Es, Mariëlle van Gijn, Orbicia Riccio et al. · Nature · 2005 · 1.5K citations · Full text

, , +15

Mutations of mitotic checkpoint genes in human cancers

Daniel P. Cahill, Christoph Lengauer, Jian Yu et al. · Nature · 1998 · 1.5K citations

, , +14

Notch signals control the fate of immature progenitor cells in the intestine

Silvia Fré, Mathilde Huyghe, Philippos Mourikis et al. · Nature · 2005 · 911 citations

, , +14