Antidiabetic and Hypocholesrolemic effect of Different Types of Vinegar in Rats

Abstract

Abstract: Vinegar is a traditional remedy for aliments including diabetes. This study was conducted to investigate the effects of different types of vinegar (sugarcane, apple, grape, coconut, artificial and palm vinegar) on serum Biochemical and Histopathological of pancreas and stomach of diabetic rats for 6 weeks at 15 % concentration. The results indicated that, all of vinegar caused significant decrease P< 0.05 in glucose, TC, LDL-c and significant increase in HDL cholesterol. Apple vinegar was the most effective to decrease glucose, TC and LDL-c followed by grape, sugarcane, coconut, artificial and palm vinegar. Apple vinegar contained the higher concentration of organic acid and phenolic compound compared to other vinegar. Apple vinegar and grape vinegar were the most effective to decrease liver and kidney function. Administrating 15 % vinegar with diet for 6 weeks decrease the food intake and feed efficiency ratio compared to control group. Moreover, administration different types of vinegar showed that no histopathological change in stomach and has protected effect of pancreas from undesirable change in B cells. In conclusion, using the different types of vinegar with diet for 6 weeks have beneficial effects on diabetic rats and have hypocholesterolemic effect. The vinegar did not effect on stomach histopathological structure and have protective effect of pancreas from damage. [Sahar S.A. Soltan and Manal M. E. M. Shehata. Antidiabetic and Hypocholesrolemic effect of Different Types of