Concepedia

Keto-1,3,4-oxadiazoles as cathepsin K inhibitors

James T. Palmer, Bernard L. Hirschbein, Harry Cheung, John D. McCarter, James W. Janc, Z. Walter Yu, Gregg Wesolowski

Bioorganic & Medicinal Chemistry Letters · 2006 · 68 citations · 16 references

DOIFull text

Open access

Concepts

References

16

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

, , +16

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

John F. Morrison · Biochimica et Biophysica Acta (BBA) - Enzymology · 1969 · 814 citations

, , +16

Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

Dieter Brömme, Kathleen Okamoto, Bruce B. Wang et al. · Journal of Biological Chemistry · 1996 · 425 citations · Full text

, , +17

Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

Bartholomew J. Votta, Mark A. Levy, Alison M. Badger et al. · Journal of Bone and Mineral Research · 1997 · 185 citations

, , +16

Lysosomotropism of Basic Cathepsin K Inhibitors Contributes to Increased Cellular Potencies against Off-Target Cathepsins and Reduced Functional Selectivity

Jean‐Pierre Falgueyret, Sylvie Desmarais, Renata M. Oballa et al. · Journal of Medicinal Chemistry · 2005 · 153 citations · Full text

, , +17