Concepedia

Publication | Open Access

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

DOIFull Paper Access

72

Citations

37

References

2015

Year

Juliana Benito, Marc S. Ramirez, Niki M. Zacharias, Juliana Vélez, Karine G. Harutyunyan, Hongbo Lu, Yue-Xi Shi, Polina Matre, Rodrigo Jácamo, Helen Ma,
Clinical Cancer Research

Abstract

These findings implicate a pathogenic role of hypoxia in leukemia maintenance and chemoresistance and demonstrate the feasibility of targeting hypoxic cells by hypoxia cytotoxins.

References

YearCitations

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