Concepedia

Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC)

Michael L. Curtin, Robert B. Garland, H. Robin Heyman, Robin R. Frey, Michael R. Michaelides, Junling Li, Lori J. Pease, Keith B. Glaser, Patrick A. Marcotte, Steven K. Davidsen

Bioorganic & Medicinal Chemistry Letters · 2002 · 113 citations · 15 references

DOIFull text

Open access

Concepts

References

15

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Minoru Yoshida, Masako Kijima, Motomu Akita et al. · Journal of Biological Chemistry · 1990 · 1.9K citations · Full text

, , +17

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Michael S. Finnin, Jill R. Donigian, Alona Cohen et al. · Nature · 1999 · 1.7K citations

, , +12

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

Victoria M. Richon, Stéphane Emiliani, Eric Verdin et al. · Proceedings of the National Academy of Sciences · 1998 · 914 citations · Full text

, , +12

Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.

Masako Kijima, Minoru Yoshida, Kenji Sugita et al. · Journal of Biological Chemistry · 1993 · 512 citations · Full text

, , +14

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

Ryohei Furumai, Yasuhiko Komatsu, Norikazu Nishino et al. · Proceedings of the National Academy of Sciences · 2000 · 412 citations · Full text

, , +8