Ryohei Furumai

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

Ryohei Furumai, Akihisa Matsuyama, Nobuyuki Kobashi et al. · PubMed · 2002 · 744 citations

Reductive Stress, Disulfide Bond, Biochemistry +15

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

Ryohei Furumai, Yasuhiko Komatsu, Norikazu Nishino et al. · Proceedings of the National Academy of Sciences · 2000 · 410 citations · Full text

Hdac6 Inhibition, Bioorganic Chemistry, Aldo-keto Reductase +20

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

Kazuho Nishimura, Takuya Kumazawa, Takao Kuroda et al. · Cell Reports · 2015 · 155 citations · Full text

Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity.

Yasuhiko Komatsu, Kin‐ya Tomizaki, Makiko Tsukamoto et al. · PubMed · 2001 · 146 citations

Bioorganic Chemistry, Antitumor Activity, Chemoprevention Strategy +18

ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background

Yanan Fang, Cheng-Chung Tsao, Barbara K. Goodman et al. · The EMBO Journal · 2004 · 110 citations · Full text