FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

Ryohei Furumai, Akihisa Matsuyama, Nobuyuki Kobashi, +8

PubMed

Reductive StressDisulfide BondBiochemistryMolecular RegulationMedicine +13

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

Ryohei Furumai, Yasuhiko Komatsu, Norikazu Nishino, +3

Proceedings of the National Academy of Sciences

Hdac6 InhibitionBioorganic ChemistryAldo-keto ReductasePharmacotherapyAntimicrobial Chemotherapy +18

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

Kazuho Nishimura, Takuya Kumazawa, Takao Kuroda, +7

Cell Reports

Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity.

Yasuhiko Komatsu, Kin‐ya Tomizaki, Makiko Tsukamoto, +9

PubMed

Bioorganic ChemistryAntitumor ActivityChemoprevention StrategyAldo-keto ReductaseHdac Activity +16

ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background

Yanan Fang, Cheng-Chung Tsao, Barbara K. Goodman, +4

The EMBO Journal

Stable RNA Interference–Mediated Suppression of Cyclophilin A Diminishes Non–Small-Cell Lung Tumor Growth <i>In vivo</i>

Brandon A. Howard, Ryohei Furumai, Michael J. Campa, +4

Cancer Research

Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation

Ji Zhang, Shideng Bao, Ryohei Furumai, +4

Molecular and Cellular Biology

ApoptosisCell DeathCell CycleProtein Phosphatase 5Oxidative Stress +16

Spliceostatin A blocks angiogenesis by inhibiting global gene expression including <i>VEGF</i>

Ryohei Furumai, Kazuyo Uchida, Yusuke Komi, +5

Cancer Science

Neuronal Differentiation of Neuro 2a Cells by Inhibitors of Cell Cycle Progression, Trichostatin A and Butyrolactone I

Junji Inokoshi, Masako KATAGIRI, Shiho Arima, +7

Biochemical and Biophysical Research Communications

Neuro 2ADevelopmental BiologyNeuroanatomyNeuronal DifferentiationNeuropharmacology +8

The role of class I histone deacetylase (HDAC) on gluconeogenesis in liver

Hiroshi Oiso, Noboru Furukawa, Mihoshi Suefuji, +7

Biochemical and Biophysical Research Communications

ChromatinHepatologyBiochemistryChromatin RemodelingNatural Sciences +11