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Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

Pde4 InhibitorsMedicinal ChemistryNatural SciencesMedicineRational Drug DesignPde4 InhibitorSubstituted 8-Arylquinoline SeriesOrganic ChemistryChemistryPharmacologyPharmaceutical ChemistryDrug Discovery