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Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

Dwight Macdonald, Anthony Mastracchio, Hélène Perrier, Daniel Dubé, Michel Gallant, Patrick Lacombe, Denis Deschênes, Bruno Roy, John Scheigetz, Kevin P. Bateman,

Bioorganic & Medicinal Chemistry Letters · 2005 · 30 citations · 16 references

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Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity

Robert X. Xu, Anne M. Hassell, Dana E. Vanderwall et al. · Science · 2000 · 334 citations

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1,4-Cyclohexanecarboxylates:  Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

Siegfried B. Christensen, Aimee M. Guider, Cornelia J. Forster et al. · Journal of Medicinal Chemistry · 1998 · 150 citations · Full text

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The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise‐Induced Asthma and Leads to Suppression of LPS‐Stimulated TNF‐α Ex Vivo

Wolfgang Timmer, V. Leclerc, Guillaume Birraux et al. · The Journal of Clinical Pharmacology · 2002 · 123 citations

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The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects

P.L. Harbinson, D MacLeod, Richard J. Hawksworth et al. · European Respiratory Journal · 1997 · 121 citations

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Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor

David Claveau, S L Chen, Stephen J. O’Keefe et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 101 citations

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