Bruno Roy

Discovery of a Potent and Selective Prostaglandin D₂ Receptor Antagonist, [(3<i>R</i>)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[<i>b</i>]indol-3-yl]-acetic Acid (MK-0524)

Claudio F. Sturino, Gary P. O’Neill, Nicolas Lachance et al. · Journal of Medicinal Chemistry · 2007 · 170 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +8

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Élise Isabel, Christophe Mellon, Michael J. Boyd et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 111 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +12

Process Development and Large-Scale Synthesis of a PDE4 Inhibitor

David A. Conlon, Antoinette Drahus-Paone, Guo‐Jie Ho et al. · Organic Process Research & Development · 2005 · 41 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

Dwight Macdonald, Anthony Mastracchio, Hélène Perrier et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 30 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

A SYNTHESIS OF 4-α-GUANIDINO-2-DEOXY-2,3-DIDEHYDRO N-ACETYLNEURAMINIC ACID

John Scheigetz, Robert Zamboni, Michael A. Bernstein et al. · Organic Preparations and Procedures International · 1995 · 29 citations

Natural Sciences, Chemistry, Organic Chemistry +1