Dwight Macdonald

Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

Annette Robichaud, Panagiota B. Stamatiou, S.-L. Catherine Jin et al. · Journal of Clinical Investigation · 2002 · 266 citations · Full text

Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

Annette Robichaud, Panagiota B. Stamatiou, S.-L. Catherine Jin et al. · Journal of Clinical Investigation · 2002 · 258 citations

Type 4, Anesthetic Mechanism, Rolipram-sensitive Pde Activity +24

A triply convergent enantioselective total synthesis of (+)-ikarugamycin

Leo A. Paquette, Dwight Macdonald, Lawrence G. Anderson et al. · Journal of the American Chemical Society · 1989 · 76 citations

Derivative (Chemistry), Molecular Sciences, Chemical Measurement +11

Total synthesis of (+)-ikarugamycin. 2. Elaboration of the macrocyclic lactam and tetramic acid substructures and complete assembly of the antibiotic

Leo A. Paquette, Dwight Macdonald, Lawrence G. Anderson · Journal of the American Chemical Society · 1990 · 49 citations

Bioorganic Chemistry, Altmetric Attention Score, Complete Assembly +21

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

Michel Gallant, Renée Aspiotis, Stephen H. Day et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 43 citations · Full text

Alzheimer's Disease, Medicine, Dementia +10