Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Élise Isabel, Christophe Mellon, Michael J. Boyd, +20

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryPharmaceutical ScienceDerivative (Chemistry)Biochemistry +8

Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

Momar Ndao, Christian Beaulieu, W. Cameron Black, +7

Antimicrobial Agents and Chemotherapy

Antiparasitic AgentImmunologyPathologyPharmacotherapyImmunotherapeutics +19

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

Christian Beaulieu, Élise Isabel, Angélique Fortier, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryReversible Cruzipain InhibitorsMedicinePathologyPharmacotherapy +3

Preparation, Solid-State Structure, and Synthetic Applications of Isolable and Storable Haloalkylzinc Reagents

André B. Charette, Jean-François Marcoux, Carmela Molinaro, +3

Journal of the American Chemical Society

Solid-state StructureChemical EngineeringEngineeringPhysicochemical AnalysisStorable Haloalkylzinc Reagents +10

Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series

Nicolas Lachance, Yves Gareau, Sébastien Guiral, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceLiver-targeted Stearoyl-coa DesaturaseDrug TargetBiochemistry +10

Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors

Élise Isabel, David Powell, W. Cameron Black, +12

Bioorganic & Medicinal Chemistry Letters

Biological ActivityMedicinal ChemistryAzetidinyl PyridazinesPharmacological StudyBiochemistry +9

Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis

Joël Robichaud, W. Cameron Black, Michel Thérien, +15

Journal of Medicinal Chemistry

Nicotinyl aspartyl ketones as inhibitors of caspase-3

Élise Isabel, W. Cameron Black, Christopher I. Bayly, +12

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +7

The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor

Élise Isabel, Kevin P. Bateman, Nathalie Chauret, +28

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceBiochemistryMedicineNatural Sciences +4

Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

David Powell, W. Cameron Black, Kelly Bleasby, +14

Bioorganic & Medicinal Chemistry Letters

HepatologyBiochemistryLiver-targeted Scd InhibitorsMedicineLiver Physiology +5