Christophe Mellon

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Élise Isabel, Christophe Mellon, Michael J. Boyd et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 111 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Science +10

Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

Momar Ndao, Christian Beaulieu, W. Cameron Black et al. · Antimicrobial Agents and Chemotherapy · 2013 · 103 citations · Full text

Antiparasitic Agent, Immunology, Pathology +21

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

Christian Beaulieu, Élise Isabel, Angélique Fortier et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 70 citations · Full text

Medicinal Chemistry, Reversible Cruzipain Inhibitors, Medicine +5

An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells

Jean‐Pierre Falgueyret, W. Cameron Black, Wanda Cromlish et al. · Analytical Biochemistry · 2004 · 52 citations

Protein Chemistry, Protein Function, Cellular Enzymology +8

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

Michel Gallant, Christian Beaulieu, Carl Berthelette et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 49 citations · Full text

Respiratory Diseases, Pharmacology, Mechanism Of Action +5