Siegfried B. Christensen

1,4-Cyclohexanecarboxylates:  Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

Siegfried B. Christensen, Aimee M. Guider, Cornelia J. Forster et al. · Journal of Medicinal Chemistry · 1998 · 150 citations · Full text

Suppression of human inflammatory cell function by subtype‐selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

Carol D. Manning, Miriam Burman, Siegfried B. Christensen et al. · British Journal of Pharmacology · 1999 · 143 citations · Full text

Inflammation, Anti-inflammatory, Subtype‐selective Pde4 Inhibitors +10

New Perspectives on Aflatoxin Biosynthesis

Joan W. Bennett, Siegfried B. Christensen · Advances in applied microbiology · 1983 · 137 citations

Biosynthesis, Biochemistry, Mycotoxin Formation +3

Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

Mary S. Bamette, Joan O'Leary Bartus, Miriam Burman et al. · Biochemical Pharmacology · 1996 · 106 citations

Inhibitory Activity, Anti-inflammatory, Biochemistry +8

SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo.

Don E. Griswold, Edward F. Webb, Alison M. Badger et al. · PubMed · 1998 · 86 citations

Inflammation, Cytokine, Anti-inflammatory +13