1,4-Cyclohexanecarboxylates:  Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

Siegfried B. Christensen, Aimee M. Guider, Cornelia J. Forster, +19

Journal of Medicinal Chemistry

Suppression of human inflammatory cell function by subtype‐selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

Carol D. Manning, Miriam Burman, Siegfried B. Christensen, +5

British Journal of Pharmacology

InflammationAnti-inflammatorySubtype‐selective Pde4 InhibitorsDual Pde4a/pde4b InhibitorsMedicine +8

Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.

Theodore J. Torphy, Jeffrey M. Stadel, Miriam Burman, +4

Journal of Biological Chemistry

Proteinlipid InteractionSignal TransductionBiochemistryNatural SciencesPde Iv +12

A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA.

Megan M. McLaughlin, L B Cieslinski, Miriam Burman, +2

Journal of Biological Chemistry

Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding.

Susanne Jacobitz, Mark McLaughlin, G P Livi, +2

Molecular Pharmacology

Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

Mary S. Bamette, Joan O'Leary Bartus, Miriam Burman, +6

Biochemical Pharmacology

Inhibitory ActivityAnti-inflammatoryBiochemistryMedicinePhosphodiesterase 4 +6

Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site.

Mary S. Barnette, Marilyn Grous, L B Cieslinski, +3

Journal of Pharmacology and Experimental Therapeutics

Pharmacological Characterization of GSK573719 (Umeclidinium): A Novel, Long-Acting, Inhaled Antagonist of the Muscarinic Cholinergic Receptors for Treatment of Pulmonary Diseases

M Salmon, Mark A. Luttmann, James J. Foley, +13

Journal of Pharmacology and Experimental Therapeutics

Inhibition of the low km cyclic AMP phosphodiesterase in intact canine trachealis by SK&F 94836: mechanical and biochemical responses.

T J Torphy, Miriam Burman, Liguo Huang, +1

PubMed

Experimental PharmacologyCellular PhysiologyNeuromuscular BlockadeMolecular PharmacologyBioanalysis +17

Role of cyclic nucleotide phosphodiesterase isozymes in intact canine trachealis.

Theodore J. Torphy, Han-liang Zhou, Miriam Burman, +1

Molecular Pharmacology