Patrick Lacombe

Structure–Activity Relationship of Biaryl Acylsulfonamide Analogues on the Human EP3 Prostanoid Receptor

Michel Gallant, Marie‐Claude Carrière, Anne Châteauneuf et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 46 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

Michel Gallant, Renée Aspiotis, Stephen H. Day et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 44 citations · Full text

Medicine, Neuroscience, Pharmacology +11

Reduction of olefins on solid support using diimide

Patrick Lacombe, Bastien Castagner, Yves Gareau et al. · Tetrahedron Letters · 1998 · 30 citations

Natural Sciences, Chemistry, Materials Science +8

L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition

Zheng Huang, Rebecca Dias, Tom R. Jones et al. · Biochemical Pharmacology · 2007 · 30 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

Dwight Macdonald, Anthony Mastracchio, Hélène Perrier et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 30 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16