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Non-covalent thrombin inhibitors featuring P3-Heterocycles with P1-Bicyclic arginine surrogates

Jingrong Jean Cui, Gian‐Luca Araldi, John Reiner, Komandla Malla Reddy, Scott J. Kemp, Jonathan Z. Ho, Daniel V. Siev, Lala Mamedova, Tony Gibson, John Gaudette,

Bioorganic & Medicinal Chemistry Letters · 2002 · 27 citations · 33 references

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33

Arginine mimetics

Lucíja Peterlin Mašič, D. Kikelj · Tetrahedron · 2001 · 135 citations

Efficient Synthesis of 5-(Bromomethyl)- and 5-(Aminomethyl)-1-THP-Indazole

Jung‐Hui Sun, Christopher A. Teleha, Jia-Sheng Yan et al. · The Journal of Organic Chemistry · 1997 · 128 citations

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Structural and Functional Characterization of Tick Anticoagulant Peptide (TAP): A Potent and Selective Inhibitor of Blood Coagulation Factor Xa

George P. Vlasuk · Thrombosis and Haemostasis · 1993 · 110 citations

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Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Philip E.J. Sanderson, Terry A. Lyle, Kellie J. Cutrona et al. · Journal of Medicinal Chemistry · 1998 · 85 citations · Full text

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Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor <i>N</i>-(9-Hydroxy-9-fluorenecarboxy)prolyl <i>trans</i>-4-Aminocyclohexylmethyl Amide (L-372,460):  Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support

Stephen F. Brady, Kenneth J. Stauffer, William C. Lumma et al. · Journal of Medicinal Chemistry · 1998 · 78 citations · Full text

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