Concepedia

Thrombin Generation

Thrombin Generation is the dynamic biochemical process within the coagulation cascade by which prothrombin is enzymatically converted to active thrombin over time, thereby determining the magnitude and temporal profile of thrombin activity that drives fibrin formation, platelet activation, and regulation of hemostasis.

13.1K

Publications

686.6K

Citations

37.8K

Authors

5.1K

Institutions

Publications per year

2017–2026

1.2K

Parents

Children

Publications

13.1K

Mutation in blood coagulation factor V associated with resistance to activated protein C

Rogier M. Bertina, Bobby P. C. Koeleman, Ted Koster et al. · Nature · 1994 · 3.8K citations

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A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

SR Poort, FR Rosendaal, PH Reitsma et al. · Blood · 1996 · 3.1K citations · Full text

, , +15

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

Louis C. Bock, Linda C. Griffin, John Latham et al. · Nature · 1992 · 2.5K citations

, , +13

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells <i>In Vitro</i>

Russell Ross, John Glomset, Beverly Kariya et al. · Proceedings of the National Academy of Sciences · 1974 · 1.9K citations · Full text

, , +9

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

Kun‐Liang Guan, J.E. Dixon · Analytical Biochemistry · 1991 · 1.8K citations

, , +16

1–5 of 13.1K

Authors

37.8K

  1. KG
    Kenneth G. Mann

    University of Vermont, United States

    119 publications · 11.7K citations

    63

    h-index

  2. HH
    H.C. Hemker

    Maastricht University, Netherlands

    133 publications · 10.8K citations

    48

    h-index

  3. CT
    Charles T. Esmon

    Oklahoma Medical Research Foundation, United States

    62 publications · 9.6K citations

    43

    h-index

  4. HT
    Hugo Ten Cate

    Maastricht University, Netherlands

    77 publications · 5.6K citations

    42

    h-index

  5. JW
    John W. Fenton

    New York State Department of Health, United States

    73 publications · 5.3K citations

    40

    h-index

1–5 of 37.8K

Institutions

5.1K

  1. Maastricht University

    Maastricht, The Netherlands

    67 h-index

    930 publications

    62.7K citations

  2. Washington University in St. Louis

    St Louis, United States

    64 h-index

    451 publications

    44.8K citations

  3. University of Vermont

    Burlington, United States

    63 h-index

    456 publications

    38.6K citations

  4. Harvard University

    Cambridge, United States

    62 h-index

    554 publications

    42.6K citations

  5. Inserm

    Paris, France

    62 h-index

    1.1K publications

    66.6K citations

  6. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    61 h-index

    661 publications

    39.4K citations

  7. University of Pennsylvania

    Philadelphia, United States

    56 h-index

    444 publications

    32.3K citations

  8. University of Michigan

    Ann Arbor, United States

    51 h-index

    370 publications

    28.8K citations

1–8 of 5.1K

Venues

  1. Blood

    725 publications · 63.7K citations

    133

    h-index

  2. Journal of Biological Chemistry

    JBC · 582 publications · 50.9K citations

    112

    h-index

  3. Thrombosis and Haemostasis

    921 publications · 49.8K citations

    99

    h-index

  4. Journal of Thrombosis and Haemostasis

    JTH · 424 publications · 23.4K citations

    85

    h-index

  5. PubMed

    Repository · 702 publications · 26.9K citations

    79

    h-index

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