Christopher A. Teleha

MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

John V. Duncia, Joseph B. Santella, C. Anne Higley et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 404 citations · Full text

Biological Activity, Mek Inhibitors, Medicinal Chemistry +12

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-<i>N</i>-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1<i>H</i>-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Mimi L. Quan, Patrick Y. S. Lam, Qi Han et al. · Journal of Medicinal Chemistry · 2004 · 188 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Pharmaceutical Chemistry +17

Efficient Synthesis of 5-(Bromomethyl)- and 5-(Aminomethyl)-1-THP-Indazole

Jung‐Hui Sun, Christopher A. Teleha, Jia-Sheng Yan et al. · The Journal of Organic Chemistry · 1997 · 127 citations

Medicinal Chemistry, Diversity Oriented Synthesis, Engineering +13

Structure-Based Design of Novel Guanidine/Benzamidine Mimics:  Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants

Patrick Y. S. Lam, Charles G. Clark, Renhua Li et al. · Journal of Medicinal Chemistry · 2003 · 95 citations · Full text

Pharmaceutical Science, Oral Bioavailability, Pharmacotherapy +18

Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Chu‐Biao Xue, Matthew E. Voss, David J. Nelson et al. · Journal of Medicinal Chemistry · 2001 · 79 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, Pharmaceutical Chemistry +17