Joseph B. Santella

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives

David J. Carini, John V. Duncia, Paul E. Aldrich et al. · Journal of Medicinal Chemistry · 1991 · 431 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

John V. Duncia, Joseph B. Santella, C. Anne Higley et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 406 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11

Three synthetic routes to a sterically hindered tetrazole. A new one-step mild conversion of an amide into a tetrazole

John V. Duncia, Michael E. Pierce, Joseph B. Santella · The Journal of Organic Chemistry · 1991 · 315 citations

Natural Sciences, Chemistry, Medicinal Chemistry +7

DBS Sampling Can be Used to Stabilize Prodrugs in Drug Discovery Rodent Studies without the Addition of Esterase Inhibitors

Celia D’Arienzo, Qin Ji, Lorell Discenza et al. · Bioanalysis · 2010 · 78 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

Shailesh Dudhgaonkar, Sourabh Ranade, Jignesh Nagar et al. · The Journal of Immunology · 2016 · 74 citations · Full text

Life Sciences, Immunology, Pharmacology +17