Paul E. Aldrich

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives

David J. Carini, John V. Duncia, Paul E. Aldrich et al. · Journal of Medicinal Chemistry · 1991 · 431 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Cyclic HIV Protease Inhibitors:  Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas

Patrick Y. S. Lam, Yu Ru, Prabhakar K. Jadhav et al. · Journal of Medicinal Chemistry · 1996 · 170 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

C. Nicholas Hodge, Paul E. Aldrich, Lee T. Bacheler et al. · Chemistry & Biology · 1996 · 148 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +16

In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease.

M. J. Otto, Sena Garber, Dean L. Winslow et al. · Proceedings of the National Academy of Sciences · 1993 · 129 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +17

β-HYDROXY-β-METHYL-δ-VALEROLACTONE (DIVALONIC ACID), A NEW BIOLOGICAL FACTOR

Donald E. Wolf, Carl H. Hoffman, Paul E. Aldrich et al. · Journal of the American Chemical Society · 1956 · 103 citations

Pharmacy, Biochemistry, Chemistry +5